Role of JAK-STAT3 signaling pathway during neuronal differentiation of rat bone marrow mesenchymal stem cells….

The article presents a study on the role of Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signaling pathway during neuronal differentiation of mesenchymal stem cells (MSCs) using the JAK-STAT3 signaling inhibitor AG490 and growth factors. After the assignment of passage 3 MSCs to non-induced, growth factor and AG490 groups, MSCs were transdifferentiated into phenotypes through the induction of several growth factors. It is concluded that neuronal induction of bone marrow MSCs was regulated by JAK-STAT3 signaling pathway.