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Common Genetic Variants, QT Interval, and Sudden Cardiac Death in a Finnish Population-Based Study.

Authors :
Noseworthy, Peter A.
Havulinna, Aki S.
Porthan, Kimmo
Lahtinen, Annukka M.
Jula, Antti
Karhunen, Pekka J.
Perola, Markus
Oikarinen, Lasse
Kontula, Kimmo K.
Salomaa, Veikko
Newton-Cheh, Christopher
Source :
Circulation: Cardiovascular Genetics; Jun2011, Vol. 4 Issue 3, p305-311, 7p
Publication Year :
2011

Abstract

The article discusses a study of a large, population-based cohort in Finland to replicate the association of common genetic variants with QT interval, confirm the relationship between QT interval and sudden cardiac death (SCD) and explore the association between a score reflecting the joint influence of the variants and risk of SCD. It strongly replicates the association between common genetic variants and the QT interval and suggests a relationship between said variants in aggregate and SCD.

Details

Language :
English
ISSN :
1942325X
Volume :
4
Issue :
3
Database :
Supplemental Index
Journal :
Circulation: Cardiovascular Genetics
Publication Type :
Academic Journal
Accession number :
63206542
Full Text :
https://doi.org/10.1161/CIRCGENETICS.110.959049