PPAR-γ2 Pro12Ala polymorphism is associated with post-challenge abnormalities of glucose homeostasis in children and adolescents with obesity.

The article presents a study investigating the association between the peroxisome proliferator activated receptor (PPAR)-γ2 Pro12Ala polymorphism and the laboratory characteristics of carbohydrate metabolism in 79 obese children and adolescents. It reports that Ala allele carriers showed lower plasma glucose and insulin values than homozygous Pro allele carriers at the post-challenge (120 minutes) stage. It therefore suggests that the Ala allele may protect against the development of abnormal glucose homeostasis in childhood obesity.