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Effects of Oligonol®, an oligomerized polyphenol formulated from lychee fruit, on serum concentration and urinary excretion of uric acid.
- Source :
- Journal of Functional Foods; Jan2011, Vol. 3 Issue 1, p13-16, 4p
- Publication Year :
- 2011
-
Abstract
- Abstract: Epidemiological observations and laboratory studies have suggested that polyphenols possess anti-inflammatory, anti-microbial, anti-carcinogenic, and antioxidant properties. However, studies assessing the effects of polyphenols on uric acid metabolism in vivo are scarce. Herein, we investigated whether a phenolic substance, Oligonol®, has effects on uric acid metabolism. In six healthy male volunteers, Oligonol® significantly decreased 1-h uric acid excretion and fractional uric acid clearance, which was accompanied by a decreased serum concentration of uric acid. In addition, an in vitro experiment showed that Oligonol® inhibited buttermilk xanthine oxidase activity in a dose-dependent manner. Together, these results suggest that Oligonol® lowers serum uric acid through inhibition of xanthine oxidase, and may be effective for prevention and treatment of hyperuricemia and/or gout. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 3
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Functional Foods
- Publication Type :
- Academic Journal
- Accession number :
- 59659159
- Full Text :
- https://doi.org/10.1016/j.jff.2010.11.002