Mechanisms of In-Stent Restenosis After Drug-Eluting Stent Implantation.

The article discusses a study that clarified the main mechanisms of in-stent restenosis (ISR) especially at the minimum lumen site. It points out that angiographic restenosis was observed in 348 lesions treated with drug-eluting stents (DES) from August 2004 and December 2007. The findings indicated that the most common DES restenosis pattern is focal especially in sirolimus-eluting stents (SES) and that the magnitude of intimal hyperplasia (IH) was greater in paclitaxel-eluting stents (PES) than in other DES.