Associations of Folate, Vitamin B12, Homocysteine, and Folate-Pathway Polymorphisms with Prostate-Specific Antigen Velocity in Men with Localized Prostate Cancer.

The article presents a study on the roles of folate, vitamin B₁₂, homocysteine and folate-pathway polymorphisms in determining prostate-specific antigen velocity (PSAV) in men diagnosed with localized prostate cancer. For the study, researchers examined 424 men in Great Britain with prostate cancer. They found that vitamin B₁₂, holo-haptocorrin, holo-transcobalamin, total transcobalamin, and total homocysteine were not linked to postdiagnosis PSAV. They found little evidence on the link of higher folate with cancer progression.