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Cytochrome P450 2D6 inhibitory constituents of Lunasia amara.
- Source :
- Phytochemistry Letters; Mar2011, Vol. 4 Issue 1, p30-33, 4p
- Publication Year :
- 2011
-
Abstract
- Abstract: From a MeOH extract of Lunasia amara, which showed the cytochrome P450 2D6 (CYP2D6) inhibition, 14 acridone alkaloids including two new alkaloids [5-hydoroxygraveoline (1) and 8-methoxyifflaiamine (2)] were identified. Among the 14 acridone alkaloids, 5-hydoroxygraveoline (1) and lunamarine (3) showed moderate inhibition selective for CYP2D6, with IC<subscript>50</subscript> values of 4.7μM and 1.8μM, respectively. [Copyright &y& Elsevier]
- Subjects :
- CYTOCHROME P-450
RUTACEAE
ALKALOIDS
AMINES
METHANOL
PLANT extracts
CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 18743900
- Volume :
- 4
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Phytochemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 58543134
- Full Text :
- https://doi.org/10.1016/j.phytol.2010.10.006