Vasoconstrictor Potential of Coronary Aspirate From Patients Undergoing Stenting of Saphenous Vein Aortocoronary Bypass Grafts and Its Pharmacological Attenuation.

The article presents a study which aimed to quantify the release of vasoconstrictors during stent implantation into atherosclerotic plaques and to determine the efficacy of coronary dilators to attenuate their action. Results showed serotonin as the main coronary vasoconstrictor released after stenting with thromboxane and tumor necrosis factor (TNF)α potentiating the response. Nitroprusside and verapamil were found to be more potent than adenosine in attenuating the aspirate plasma-induced vasoconstriction.