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Atrial Fibrillation Induces Myocardial Fibrosis Through Angiotensin II Type 1 Receptor--Specific Arkadia-Mediated Downregulation of Smad7.
- Source :
- Circulation Research; 1/21/2011, Vol. 108 Issue 2, p164-175, 12p, 2 Charts, 6 Graphs
- Publication Year :
- 2011
-
Abstract
- The article examines the role of the Angiotensin II (Ang II)/Ang II type 1 (AT<subscript>1</subscript>) receptor-coupled transforming growth factor (TGF)-β-<subscript>1</subscript>/Smad signaling pathway in the atrial fibrillation (AF)-induced myocardial fibrosis. It is shown that significant downregulation of Smad7 expression in rabbit atria and an increase in P-Smad2/3 activity and atrial fibrosis result from RAP-induced AF.
- Subjects :
- ANGIOTENSIN II
ATRIAL fibrillation
TRANSFORMING growth factors
CYTOKINES
RABBITS
Subjects
Details
- Language :
- English
- ISSN :
- 00097330
- Volume :
- 108
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Circulation Research
- Publication Type :
- Academic Journal
- Accession number :
- 57952397
- Full Text :
- https://doi.org/10.1161/CIRCRESAHA.110.234369