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Role of the M2 haplotype within the annexin A5 gene in the occurrence of pregnancy-related venous thromboembolism.
- Source :
- American Journal of Obstetrics & Gynecology; Nov2010, Vol. 203 Issue 5, p461.e1-461.e5, 0p
- Publication Year :
- 2010
-
Abstract
- Objective: Knowledge about risk factors for venous thromboembolism (VTE) is still limited. A recently found haplotype within the natural anticoagulant protein annexin A5 (ANXA5) exerts an important modulating effect on gene expression. Study Design: Eighty-three nonanticoagulated patients with a documented pregnancy-related VTE and 195 controls were investigated. The presence of the ANXA5 haplotypes was determined. Results: Twenty-seven patients (32.5%) carried the M2 haplotype. Among them, 17 (63.0%) had a history of VTE in puerperium and 10 (37.0%) during pregnancy. The prevalence of the M2 haplotype was different as compared with that recorded among controls (odds ratio, 2.7; 95% confidence interval, 1.5–4.9, P < .001). A logistic regression analysis, correcting for potential confounders (age at which the thrombotic event occurred, factor V Leiden, and factor IIA20210 variants) showed a significant increase (odds ratio, 3.4; 95% confidence interval, 1.7–6.7) of the occurrence of VTE in carriers of the M2 haplotype as compared with noncarriers. Conclusion: The M2 haplotype within the ANXA5 gene may represent a new thrombophilic risk factor for pregnancy-related VTE. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00029378
- Volume :
- 203
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- American Journal of Obstetrics & Gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 55054993
- Full Text :
- https://doi.org/10.1016/j.ajog.2010.06.007