Fine Mapping of the Insulin-Induced Gene 2 Identifies a Variant Associated With LDL Cholesterol and Total Apolipoprotein B Levels.

The article focuses on a study which hypothesized that human insulin-induced gene 2 (INSIG2) variants may have a role in the regulation of plasma lipid and lipoprotein levels. Study authors genotyped 32 single nucleotide polymorphisms (SNPs) in 645 individuals from the Quebec Family Study. They found two SNPs that are associated with plasma low-density lipoprotein cholesterol (LDL-C) and total apolipoprotein B (apoB) levels. Study authors concluded that INSIG2 genetic variants have direct role in lip and lipoprotein metabolism.