Receptor Activator of Nuclear Factor κB Ligand Is a Novel Inducer of Tissue Factor in Macrophages.

The article discusses research on the role of the receptor activator of nuclear factor κB ligand (RANKL) that influences the expression and activity of tissue factor (TF) to initiate the coagulation cascade. The study used chromogenic assay and semiquantitative reverse transcription polymerase chain reaction (semiquantitative RT-PCR) to determine the procuagulant and the level activites in macrophages. The study concluded that RANKL can induce TF in macrophages.