Gene Delivery of Sarcoplasmic Reticulum Calcium ATPase Inhibits Ventricular Remodeling in Ischemic Mitral Regurgitation.

The article focuses on the role of gene delivery of sarcoplasmic reticulum calcium ATPase (SERCA2a) in inhibiting ventricular modeling in mitral regurgitation (MR), a condition that doubles the chances of death in heart failure (HF) patients. The concept is tested through 12 sheep using gene delivery. The study concluded that gene delivery enhances the role of the SERCA2a inhibitor in fixing the ventricles of the heart and reduces the chances of an MR-associated death.