Genetic Architecture Underlying Variation in Extent and Remodeling of the Collateral Circulation.

The article attempts to identify candidate loci responsible for genetic-dependent variation in collateral circulation. The authors reported that four quantitative trait loci (QTL) were derived for collateral number, including epistasis between two loci. They were also able to map a QTL that was identical with the strongest QTL for chromosome 7 collateral number. They concluded that collateral extent and remodeling are heritable complex traits.