Intramyocardial VEGF-B167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated Cardiomyopathy.

Authors :: Pepe, Martino
Mamdani, Mohammed
Zentilin, Lorena
Csiszar, Anna
Qanud, Khaled
Zacchigna, Serena
Ungvari, Zoltan
Puligadda, Uday
Moimas, Silvia
Xiaobin Xu
Edwards, John G.
Hintze, Thomas H.
Giacca, Mauro
Recchia, Fabio A.
Source :: Circulation Research; 6/25/2010, Vol. 106 Issue 12, p1893-1903, 11p, 3 Diagrams, 1 Chart, 7 Graphs
Publication Year :: 2010
Abstract: The article presents a study which aimed to test the hypothesis that vascular endothelial growth factor (VEGF)-B exerts non-angiogenesis-related cardioprotective effects in nonischemic dilated cardiomyopathy. The study revealed that exogenous VEGF-B<subscript>167</subscript> exerted a compensatory receptor stimulation in paced dogs. The researchers found a cardioprotective effect of VEGF-B<subscript>167</subscript> in nonischemic dilated cardiomyopathy.

Subjects :: VASCULAR endothelial growth factors
CARDIOTONIC agents
VASODILATION
CARDIOMYOPATHIES
LABORATORY dogs

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