Increased Coupled Gating of L-Type Ca2+ Channels During Hypertension and Timothy Syndrome.

The article focuses on a study investigating the coordination of Cav1.2 or L-Type Ca2+ channels which are vital regulators for muscle and neural functions. It reports that couple gating of the channels represent a new mechanism of Ca2+ influx regulation and excitability in neurons, cardiac and arterial smooth muscle under physiological and pathological conditions. It mentions that Cav1.2 channels can open and close in tandem and increase in frequency in hypertensive smooth muscle cells.