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Severe neonatal renal failure after maternal use of angiotensin II type I receptor antagonists.

Authors :
Sinelli, M. T.
Cattarelli, D.
Cortinovis, S.
Maroccolo, D.
Chirico, G.
Source :
Medical & Surgical Pediatrics / Pediatria Medica e Chirurgica; nov/dic2008, Vol. 30 Issue 6, p306-308, 3p, 2 Black and White Photographs, 1 Chart
Publication Year :
2008

Abstract

The article describes the case of severe renal failure in a 36-week old baby girl whose mother had taken Olmesartan for hypertension during her last month of pregnancy. The baby died of cardio-circulatory failure 45 days after her birth with kidneys showing severe tubular dysgenesis. Also included is information on sartans as treatment for arterial hypertension and role of renin-angiotensin components in kidney development. The study concludes that exposure to sartans during the last month of pregnancy can cause congenital malformations, renal impairment, and fetal or neo-natal death.

Details

Language :
English
ISSN :
03915387
Volume :
30
Issue :
6
Database :
Supplemental Index
Journal :
Medical & Surgical Pediatrics / Pediatria Medica e Chirurgica
Publication Type :
Academic Journal
Accession number :
47671237