Role of Ca2+/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy.

The article discusses the study which aims to examine the role of cyclic nucleotide phosphodiesterases (PDE1) in balancing intracellular cardiomyocyte hypertrophy and cyclic guanosine monophosphate (cGMP). In the process, PDE1A used small interfering RNA to neonatal and adult rat ventricular myocytes in determining the chronic isoproterenol infusion in vivo in human hearts. Thus, PDE1A reduced the intracellular cGMP and cGMP-dependent protein kinase towards cardiomyocyte hypertrophy.