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Beta-cell autoantibodies and their function in Taiwanese children with type 1 diabetes mellitus.
- Source :
- Journal of the Formosan Medical Association; Nov2009, Vol. 108 Issue 11, p856-861, 6p
- Publication Year :
- 2009
-
Abstract
- <bold>Background/purpose: </bold>To understand the importance of autoimmunity in the development of type 1 diabetes in Taiwanese children, we evaluated the presence of beta-cell autoantibodies and their correlation with residual beta-cell function.<bold>Methods: </bold>From 1989 to 2006, 157 Taiwanese children with newly diagnosed type 1 diabetes were enrolled in this study. We determined the presence of beta-cell autoantibodies, such as glutamic acid decarboxylase autoantibodies (GADAs), insulinoma antigen 2 autoantibodies (IA-2As), and insulin autoantibodies (IAAs). A 6-minute glucagon test was also performed at diagnosis.<bold>Results: </bold>At diagnosis, 73% of children tested positive for GADAs, 76% for IA-2As and 21% for IAAs. Ninety-two percent of them had at least one of the beta-cell autoantibodies detected. Positivity for IAAs was more frequent in patients younger than 5 years than in those older than 5 years (45% vs. 13%). Using multiple regression analysis, the presence of GADAs or IAAs, or age of onset of these patients was an independent factor for residual beta-cell function. Younger patients and those with GADAs had less residual beta-cell function at disease onset, whereas those with IAAs had more insulin reserve.<bold>Conclusion: </bold>Autoimmunity plays an important role in the pathogenesis of type 1 diabetes in Taiwanese children, and the presence of IAAs tends to be more common in younger children. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09296646
- Volume :
- 108
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Journal of the Formosan Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 45558253
- Full Text :
- https://doi.org/10.1016/S0929-6646(09)60417-4