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Photodynamic Therapy as an Innovative Treatment for Malignant Pleural Mesothelioma.
- Source :
- Seminars in Thoracic & Cardiovascular Surgery; Jun2009, Vol. 21 Issue 2, p177-187, 11p
- Publication Year :
- 2009
-
Abstract
- Photodynamic therapy (PDT) of the pleura is an experimental treatment aimed at eradicating residual microscopic disease after macroscopic complete resection of malignant pleural mesothelioma (MPM) by means of intracavitary administration. A light-based treatment, PDT consists of 3 components: a nontoxic photosensitizing compound, oxygen, and visible light. The treatment is FDA-approved for several oncological targets, but remains experimental for MPM. PDT can be combined with lung-sparing pleurectomy and decortication and does not preclude other treatments such as adjuvant chemotherapy and/or radiation therapy. Additionally, PDT appears to bolster an immunologic effect by rendering the cancer cells that have been destroyed by the light-activated photosensitizer more presentable to the immune system. Local control and survival rates have been sufficiently rewarding to merit ongoing development of this combination of surgical technique and PDT. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 10430679
- Volume :
- 21
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Seminars in Thoracic & Cardiovascular Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 44630604
- Full Text :
- https://doi.org/10.1053/j.semtcvs.2009.07.001