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Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques.
- Source :
- Circulation Research; 7/17/2009, Vol. 105 Issue 2, p128-137, 10p, 3 Diagrams, 4 Graphs
- Publication Year :
- 2009
-
Abstract
- The article presents a study which describes a mechanism of pentamer C-reactive protein (pCRP) dissociation to mCRP mediated by cell membranes on activated platelets and apoptotic monocytic THP-1 and Jurkat T cells. Result shows that mCRP generation via pCRP dissociation on activated platelets and H<subscript>2</subscript>O<subscript>2</subscript>-treated apoptotic THP-1 and Jurkat T cells. It concludes that the mechanism provides a potential link between the cardiovascular risk marker and circulating pCRP.
Details
- Language :
- English
- ISSN :
- 00097330
- Volume :
- 105
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Circulation Research
- Publication Type :
- Academic Journal
- Accession number :
- 43800167
- Full Text :
- https://doi.org/10.1161/CIRCRESAHA.108.190611