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A series of critically challenging case scenarios in moderate to severe psoriasis: A Delphi consensus approach.

Authors :
Strober, Bruce
Berger, Emily
Cather, Jennifer
Cohen, David
Crowley, Jeffrey J.
Gordon, Kenneth B.
Gottlieb, Alice
Horn, Elizabeth J.
Kavanaugh, Arthur F.
Korman, Neal J.
Krueger, Gerald G.
Leonardi, Craig L.
Menter, Alan
Schwartzman, Sergio
Sobell, Jeffrey M.
Young, Melodie
Source :
Journal of the American Academy of Dermatology; Jul2009 Supplement 1, Vol. 61 Issue i1, pS1-S46, 0p
Publication Year :
2009

Abstract

Clinical trials for systemic psoriasis therapy typically enroll healthy patients and exclude patients with cardiovascular disease, latent tuberculosis, liver disease, histories of malignancies, viral infections, children, and pregnant or breast-feeding women. Physicians often require guidance for optimum management of severe psoriasis in patients that have a combination of underlying disease states. To provide treatment recommendations for complex psoriasis scenarios, a consensus panel comprising 15 experts in psoriatic disease convened to review and discuss available evidence-based data and to arrive at a consensus for treatment options of difficult cases. An application of the Delphi Method was used to select case scenarios, provide medical treatment options, present the case study with existing medical evidence, and anonymously vote on treatment options. The top 10 treatment options were ranked and statistically analyzed to compare the differences between treatments. The final rankings and analysis provide guidance for practical, safe, and efficacious treatment options in a number of complex psoriasis scenarios. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
01909622
Volume :
61
Issue :
i1
Database :
Supplemental Index
Journal :
Journal of the American Academy of Dermatology
Publication Type :
Academic Journal
Accession number :
41683286
Full Text :
https://doi.org/10.1016/j.jaad.2009.03.017