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Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum.
- Source :
- Phytochemistry Letters; Apr2009, Vol. 2 Issue 2, p77-80, 4p
- Publication Year :
- 2009
-
Abstract
- Abstract: Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC<subscript>50</subscript> value of 969μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a K <subscript> i </subscript> of 762μM. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 18743900
- Volume :
- 2
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Phytochemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 37351639
- Full Text :
- https://doi.org/10.1016/j.phytol.2008.12.003