Induction of Prostacyclin by Steady Laminar Shear Stress Suppresses Tumor Necrosis Factor-a Biosynthesis via Heme Oxygenase-1 in Human Endothelial Cells.

The article presents a study which examines the importance of COX-2-dependent prostanoids induction in the endothelial cells through laminar shear stress (LSS). Result of the study shows that LSS-dependent reduction of TNF-α generation and heme oxygenase (HO)-1 induction were abolished by the selective inhibitor of COX-2. It indicates that COX-2 prostaglandin inhibition contribute to acceleration of atherogenesis in patients taking traditional nonsteroidal antiinflammatory drugs (NSAIDS).