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Bcr Kinase Activation by Angiotensin II Inhibits Peroxisome Proliferator-Activated Receptor γ Transcriptional Activity in Vascular Smooth Muscle Cells.
- Source :
- Circulation Research; 1/2/2009, Vol. 104 Issue 1, p69-78, 10p, 1 Color Photograph, 7 Graphs
- Publication Year :
- 2009
-
Abstract
- The article presents a study on the activation of B cell receptor (Bcr) kinase through angiotensin (Ang) II which inhibits the peroxisome proliferators-activated receptor (PPAR) γ transcriptional activity in vascular smooth muscle cells (VSMCs). Ang II and platelet derived growth factor-mediated inflammatory response in VSMCs is being mediated by Bcr. PPAR γ activity was reduced by Ang II and that Bcr has a critical role in the Ang II-mediated inhibition of PPAR γ activity.
Details
- Language :
- English
- ISSN :
- 00097330
- Volume :
- 104
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Circulation Research
- Publication Type :
- Academic Journal
- Accession number :
- 36119250
- Full Text :
- https://doi.org/10.1161/CIRCRESAHA.108.188409