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Bcr Kinase Activation by Angiotensin II Inhibits Peroxisome Proliferator-Activated Receptor γ Transcriptional Activity in Vascular Smooth Muscle Cells.

Authors :
Alexis, Jeffrey D.
Nadan Wang
Wenyi Che
Lerner-Marmarosh, Nicole
Sahni, Abha
Korshunov, Vyacheslav A.
Yiping Zou
Bo Ding
Chen Yan
Berk, Bradford C.
Jun-ichi Abe
Source :
Circulation Research; 1/2/2009, Vol. 104 Issue 1, p69-78, 10p, 1 Color Photograph, 7 Graphs
Publication Year :
2009

Abstract

The article presents a study on the activation of B cell receptor (Bcr) kinase through angiotensin (Ang) II which inhibits the peroxisome proliferators-activated receptor (PPAR) γ transcriptional activity in vascular smooth muscle cells (VSMCs). Ang II and platelet derived growth factor-mediated inflammatory response in VSMCs is being mediated by Bcr. PPAR γ activity was reduced by Ang II and that Bcr has a critical role in the Ang II-mediated inhibition of PPAR γ activity.

Details

Language :
English
ISSN :
00097330
Volume :
104
Issue :
1
Database :
Supplemental Index
Journal :
Circulation Research
Publication Type :
Academic Journal
Accession number :
36119250
Full Text :
https://doi.org/10.1161/CIRCRESAHA.108.188409