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Comparative evaluation of growth inhibitory effect of stereoisomers of fucoxanthin in human cancer cell lines.
- Source :
- Journal of Functional Foods; Jan2009, Vol. 1 Issue 1, p88-97, 10p
- Publication Year :
- 2009
-
Abstract
- Abstract: Inhibitory effects of geometrical isomers of fucoxanthin – characteristic carotenoid of brown seaweeds – on the growth of various cancer cells and on human leukemia (HL-60), colon cancer (Caco-2) and prostate cancer cells (PC-3 and LNCap) were comparatively evaluated. All-trans fucoxanthin was the major geometrical isomer (∼88%) found in the fresh brown seaweed (Undaria pinnatifida) apart from a small amount of 13-cis and 13′-cis isomers (∼9%). Incubation of the fucoxanthin isomeric mixtures, all-trans fucoxanthin with a small amount of 13-cis and 13′-cis isomers, produced 9′-cis isomer (5%) and increased the contents of 13-cis and 13′-cis isomers (27%). The antiproliferative effect of the mixture of 13-cis and 13′-cis isomers was stronger than all other geometrical isomers evaluated in the study. The inhibition of growth of HL-60 cells was higher in case of 13′-cis isomer followed by 13-cis and all-trans isomers. The potent inhibitory effect of 13-cis and 13′-cis fucoxanthin on HL-60 cells and Caco-2 cells could possibly be due to their higher apoptosis-inducing activity. [Copyright &y& Elsevier]
- Subjects :
- CELLULAR pathology
CANCER cells
APOPTOSIS
UNDARIA
KELPS
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 1
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Functional Foods
- Publication Type :
- Academic Journal
- Accession number :
- 36109067
- Full Text :
- https://doi.org/10.1016/j.jff.2008.09.015