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Nicotine Metabolism in Three Ethnic/Racial Groups with Different Risks of Lung Cancer.

Authors :
Derby, Kiersten S.
Cuthrell, Kristine
Caberto, Christian
Carmella, Steven G.
Franke, Adrian A.
Hecht, Stephen S.
Murphy, Sharon E.
Marchand, Loïc Le
Source :
Cancer Epidemiology, Biomarkers & Prevention; Dec2008, Vol. 17 Issue 12, p3526-3535, 10p, 5 Charts
Publication Year :
2008

Abstract

The article studies whether higher CYP2A6 activity results in the smoker extracting more nicotine and being exposed to higher levels of tobacco-specific nitrosamine and pyrene. The authors conducted a cross-sectional study of smokers among three main ethnic groups in Hawaii. The authors report that the nicotine metabolite ratio was higher in Whites than in Japanese and intermediate in Hawaiians.

Details

Language :
English
ISSN :
10559965
Volume :
17
Issue :
12
Database :
Supplemental Index
Journal :
Cancer Epidemiology, Biomarkers & Prevention
Publication Type :
Academic Journal
Accession number :
35953237
Full Text :
https://doi.org/10.1158/1055-9965.EPI-08-0424