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Acceleration of Crossbridge Kinetics by Protein Kinase A Phosphorylation of Cardiac Myosin Binding Protein C Modulates Cardiac Function.

Authors :
Tong, Carl W.
Stelzer, Julian E.
Greaser, Marion L.
Powers, Patricia A.
Moss, Richard L.
Source :
Circulation Research; 10/24/2008, Vol. 103 Issue 9, p974-982, 9p, 3 Diagrams, 2 Charts, 2 Graphs
Publication Year :
2008

Abstract

The article reports that kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C (cMyBP)-C modulates cardiac function. It is said that cardiac function requires dynamic modulation of contraction. It is cited that a phosphorylation of (cMyBP)-C may regulate crossbridge kinetics in order to modulate contraction.

Details

Language :
English
ISSN :
00097330
Volume :
103
Issue :
9
Database :
Supplemental Index
Journal :
Circulation Research
Publication Type :
Academic Journal
Accession number :
35060434
Full Text :
https://doi.org/10.1161/CIRCRESAHA.108.177683