Neurologic Complications of Therapy.

The etiology of neurotoxicity following treatment with chemotherapy and/or radiation therapy is not always obvious. Neurologic complications can be difficult to identify, diagnose appropriately, and measure. In addition, neurotoxicity may be delayed and patients may experience tumor-related mortality before the diagnosis of treatmentrelated complications. Furthermore, the signs and symptoms of neurotoxicity may resemble those of disease progression. Finally, underlying diseases, such as diabetes mellitus, infections, hypertension, paraneoplastic syndromes, age-related dementia, seizures, concomitant medications, such as antiepileptic agents, and metabolic disorders can be confounding factors [ABSTRACT FROM AUTHOR]