Ethnicity and Risk for Colorectal Cancers Showing Somatic BRAF V600E Mutation or CpG Island Methylator Phenotype.

The article discusses the results of a cohort study of residents of Melbourne, Victoria to determine CpG island methylator phenotype (CIMP) and BRAF mutation status for colorectal cancers diagnosed during follow-up. According to the authors, those of southern European origin had lower incidence of colorectal cancer that had CIMP or BRAF mutations but similar incidence of colorectal cancer without CIMP or BRAF, when compared with people of Anglo-Celtic origin.