Therapeutic intervention on preformed anti-HLA antibodies.

The presence of broadly reactive antibodies directed at allogeneic lymphocytes is a major and increasing cause of delay in transplantation of patients with end-stage renal disease. In addition, hyperimmunized status is associated with a lower graft success rate that non-immunized status, unless patients were transplanted with excellent matched graft. Hyperimmunized patients represent an increasing proportion of graft waiting list, caused by previous graft failure, pregnancies and blood transfusions. [ABSTRACT FROM AUTHOR]