Integration of Antiangiogenic Strategies Into Colorectal Cancer Treatment.

Angiogenesis is an essential step in the growth and metastases of many solid tumors,including colorectal cancer (CRC). Efforts to inhibit angiogenesis as a potential antineoplastic strategy began more than 30 yr ago, and numerous angiogenic growth factors have subsequently been identified in large bowel tumors. The most successful antiangiogenic strategy to date has focused on inhibiting vascular endothelial growth factor (VEGF). [ABSTRACT FROM AUTHOR]