Protein Complexes in SUMO Signaling.

SUMO is a small ubiquitin-related modifier implicated in control of various cellular processes including gene transcription, cell cycle, DNA repair and apoptosis. Here we describe details of the SUMO molecular machineries implicated in the formation of signaling networks that underlie the specificity in these biological processes. SUMO signaling is also altered during development of human diseases, including cancer pathogenesis, and these alterations can be explored as a possible drug target. Keywords: SUMO, Ubiquitin, NFκB, PCNA, RanGAP1, RanBP2, nucleocytoplasmic transport, reptin, KAI1, PTP1B, cancer pathogenesis [ABSTRACT FROM AUTHOR]