Pigment Epithelium-Derived Growth Factor Inhibits Fetal Bovine Serum Stimulated Vascular Endothelial Growth Factor Synthesis in Cultured Human Retinal Pigment Epithelial Cells.

The human retinal pigment epithelium (hRPE) is a monolayer of cells that is located between the photoreceptors and Bruch's membrane. Normally, it is mitotically inactive in adult eyes but sometimes it undergoes mitosis and cell division in pathologic states. Growth factors have been implicated in inducing proliferation and migration of hRPE (Kothary and Del Monte, 2003). [ABSTRACT FROM AUTHOR]