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Measuring MDR-1 by Quantitative RT-PCR.

Authors :
Walker, John M.
Brown, Robert
Böger-Brown, Uta
Bates, Susan E.
Zhan, Zhirong
Regis, Joanna
Gamelin, Erick
Source :
Cytotoxic Drug Resistance Mechanisms; 1999, p63-81, 19p
Publication Year :
1999

Abstract

Accurate determination of the expression of P-glycoprotein and its encoding mRNA, MDR-1, is key to determining the importance of this mechanism of drug resistance in the clinic. This understanding is critical to development of P-glycoprotein antagonists to block drug efflux and to overcome drug resistance. Reversal studies are best performed in diseases in which this mechanism represents the major component of drug resistance. The clearest approach to identifying these is to measure MDR-1 mRNA or P-glycoprotein in tumors at diagnosis, at the time of disease recurrence, and before and after treatment with P-glycoprotein reversal agents. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISBNs :
9780896036031
Database :
Supplemental Index
Journal :
Cytotoxic Drug Resistance Mechanisms
Publication Type :
Book
Accession number :
33148634
Full Text :
https://doi.org/10.1385/1-59259-687-8:63