Clinical Trials in the Era of Treatment Tailoring.

Tailoring cancer treatment can be defined in various ways, but it is generally accepted that this approach refers to situations where well-identified subcategories of cancer patients may obtain the greatest benefit from some type of treatment on the basis of specific predefined conditions such as clinical prognostic or predictive factors and/or biological or molecular characteristics. This is not really a new concept, however, since it has been applied for decades within the development of all cancer therapeutic modalities. Indeed, anticancer drugs have usually been tested on all tumor types and all indications until they found their niches or the category of patients for which they brought the most significant contribution. [ABSTRACT FROM AUTHOR]