Approaches to Protein Resistance on the Polyacrylonitrile-based Membrane Surface: an Overview.

Protein adsorption and/or deposition at the surface of polymeric membranes play important roles in membrane separation processes. Although polyacrylonitrile-based membranes have been used successfully in many fields, surface modifications to improve the protein resistance and hemocompatibility have received considerable interest. Various methods such as copolymerization, grafting, physical adsorption, biomacromolecule immobilization, and biomimetic modification, have been explored to build a friendly microenvironment for proteins, especially enzymes, at the membrane surface. Herein, the behaviors of proteins at the surfaces of polyacrylonitrile-based membranes are reviewed. [ABSTRACT FROM AUTHOR]