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Design and Simulation of Self-repairing DNA Lattices.
- Source :
- DNA Computing (9783540490241); 2006, p195-214, 20p
- Publication Year :
- 2006
-
Abstract
- Self-repair is essential to all living systems, providing the ability to remain functional in spite of gradual damage. In the context of self-assembly of self-repairing synthetic biomolecular systems, recently Winfree developed a method for transforming a set of DNA tiles into its self-healing counterpart at the cost of increasing the lattice area by a factor of 25. The overall focus of this paper, however, is to develop compact designs for self-repairing tiling assemblies with reasonable constraints on crystal growth. Specifically, we use a special class of DNA tiling designs called reversible tiling which when carefully designed can provide inherent self-repairing capabilities to patterned DNA lattices. We further note that we can transform any irreversible computational DNA tile set to its reversible counterpart and hence improve the self-repairability of the computational lattice. But doing the transform with an optimal number of tiles, is still an open question. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISBNs :
- 9783540490241
- Database :
- Supplemental Index
- Journal :
- DNA Computing (9783540490241)
- Publication Type :
- Book
- Accession number :
- 32891390
- Full Text :
- https://doi.org/10.1007/11925903_15