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Nickel in F430.
- Source :
- Bioinorganic Chemistry (9783540635482); 1998, p31-63, 33p
- Publication Year :
- 1998
-
Abstract
- The terminal step in methane generation by several methanogenic organisms, of which the best studied is the archaeon Methanobacterium thermoautotrophicum, is catalyzed by the enzyme S-methyl coenzyme M reductase (methylreductase, EC 1.8.-.-). This enzyme contains a macrocyclic tetrapyrrole-derived cofactor, F430, at the active site coordinating Ni(II) in the resting state. A Ni(I) state (Ni1F430) has been proposed as the active form of the cofactor. Extensive mechanistic and spectroscopic studies have been performed on the holoenzyme, isolated cofactor, and various synthetic model compounds. These studies are summarized in the present review. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISBNs :
- 9783540635482
- Database :
- Supplemental Index
- Journal :
- Bioinorganic Chemistry (9783540635482)
- Publication Type :
- Book
- Accession number :
- 32881639
- Full Text :
- https://doi.org/10.1007/BFb0103374