Arrhythmogenic Effects of β2-Adrenergic Stimulation in the Failing Heart Are Attributable to Enhanced Sarcoplasmic Reticulum Ca Load.

Authors :: Desantiago, Jaime
Xun Ai
Islam, Mohammed
Acuna, Georgia
Ziolo, Mark T.
Bers, Donald M.
Pogwizd, Steven M.
Source :: Circulation Research; 6/6/2008, Vol. 102 Issue 11, p1389-1397, 9p, 8 Graphs
Publication Year :: 2008
Abstract: The article discusses a study which examines the arrhythmogenic effecs of β-adrenergic stimulation in the failing heart. In vivo drug infusion, in vitro myocyte and biochemical studies were performed. The arrhythmogenic effects of β-adrenergic receptors ares mediated by sarcoplasmic reticulum (SR) Ca overload-induced spontaneous SR Ca release and aftercontractions.

Subjects :: BETA adrenoceptors
HEART failure
MUSCLE cells
SARCOPLASMIC reticulum
CALCIUM

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