CYP1A1, GSTM1, and GSTT1 Polymorphisms, Smoking, and Lung Cancer Risk in a Pooled Analysis among Asian Populations.

The article reports on the study which evaluates the roles of CYP1A1 polymorphisms and deletion of glutathione S-transferase (GST) in lung cancer development in Asian populations. The study conducted a pooled analysis on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. It is revealed that the CYP1A1 ⁶²³⁵C variant was associated with squamous cell lung cancer. The GSTM1-null genotype increased squamous cell lung cancer risk.