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Insulin Therapy and Colorectal Adenoma Risk Among Patients with Type 2 Diabetes Mellitus: A Case-Control Study in Korea.
- Source :
- Diseases of the Colon & Rectum; May2008, Vol. 51 Issue 5, p593-597, 5p, 4 Charts
- Publication Year :
- 2008
-
Abstract
- Patients with Type 2 diabetes mellitus may be at increased colorectal adenoma and cancer risk. Moreover, chronic insulin therapy may increase the risk of colorectal cancer among patients with Type 2 diabetes mellitus. We investigated to determine whether insulin therapy might increase the risk of colorectal adenoma among clinically confirmed patients with Type 2 diabetes mellitus. We conducted a retrospective study among patients with Type 2 diabetes mellitus who underwent total colonoscopy between January 2003 and July 2006 at Hallym University Sacred Heart Hospital. Among them (n = 325), patients with histologically confirmed colorectal adenomas (n = 100) and the same number of controls matched by age and sex were selected and analyzed. Adenoma cases showed significantly higher rate of chronic insulin therapy (more than 1 year) than controls ( P = 0.018). In multivariate regression analysis, patients who received chronic insulin therapy had three times the risk of colorectal adenoma compared with patients who received no insulin (odds ratio, 3; 95 percent confidence interval, 1.1–8.9; P = 0.04). Chronic insulin therapy was associated with increased colorectal adenoma risk among Type 2 diabetes mellitus patients. This result may provide a need for more intensive colorectal cancer screening program in patients with Type 2 diabetes mellitus, especially those who receive chronic insulin therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00123706
- Volume :
- 51
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Diseases of the Colon & Rectum
- Publication Type :
- Academic Journal
- Accession number :
- 31870648
- Full Text :
- https://doi.org/10.1007/s10350-007-9184-1