A new mRNA splice variant coding for the human EP3-I receptor isoform.

Authors :: Kotelevets, L.
Foudi, N.
Louedec, L.
Couvelard, A.
Chastre, E.
Norel, X.
Source :: Prostaglandins Leukotrienes & Essential Fatty Acids; Oct2007, Vol. 77 Issue 3/4, p195-201, 7p
Publication Year :: 2007
Abstract: Abstract: The cellular localization of prostaglandin E<subscript>2</subscript> receptors (EP) and their corresponding transcripts were investigated in human gastric and vascular tissues. A strong staining of the EP<subscript>3</subscript> receptor on the gastric glands, mucous cells, media of the mammary and pulmonary arteries was observed by immunohistochemistry. We identified a new mRNA splice variant of the EP<subscript>3</subscript> gene in human gastric fundic mucosa, mammary artery and pulmonary vessels. This EP<subscript>3-Ic</subscript> transcript contains exons 1, 2, 3, 5 and 6 of the EP<subscript>3</subscript> gene and should be translated in the EP<subscript>3-I</subscript> isoform. In addition, the EP<subscript>3-Ib</subscript>, EP<subscript>3-II</subscript>, EP<subscript>3-III</subscript>, EP<subscript>3-IV</subscript> and EP<subscript>3-e</subscript> mRNAs were detected in these tissues. [Copyright &y& Elsevier]