Regulation of E2F-Responsive Genes through Histone Modifications.

The retinoblastoma protein Rb, when targeted to E2F-responsive promoters through a direct interaction with E2F proteins, actively represses transcription. This property is shared by the two Rb-related proteins, p107 and p130. Active transcriptional repression by Rb is important for the proper control of cell growth. Many recent results have indicated that Rb represses transcription through proteins acting on chromatin structure. The purpose of this chapter is to review these results, and to discuss the possible mechanisms by which accurate regulation of E2F-responsive genes is achieved. [ABSTRACT FROM AUTHOR]