Regulation of DNA Replication by the Retinoblastoma Tumor Suppressor Protein.

RB is a critical tumor suppressor targeted at high frequency in human cancers. As part of its mode of action RB participates in the regulation of DNA replication. In the absence of functional RB aberrant replication cycles occur and genotoxic stresses are compromised for inhibiting of DNA replication. Varied mechanisms through which RB inhibits S-phase have been described and provide evidence for temporally regulated stalling of replication initiation followed by a stable replicative exit. [ABSTRACT FROM AUTHOR]