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The Effect of Interleukin-17 on Hematopoietic Cells and Cytokine Release in Mouse Spleen.
- Source :
- Physiological Research; 2007, Vol. 56 Issue 3, p331-339, 9p, 5 Graphs
- Publication Year :
- 2007
-
Abstract
- To evaluate whether the response of hematopoietic cells to interleukin-17 (IL-17) depends on the tissue microenvironment in which hematopoiesis occurs, the influence of recombinant mouse IL-17 on spleen hematopoietic cells and cytokine release was assessed in normal mice in vitro and in vivo. In vitro, IL-17 did not significantly affect the growth of granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) derived colonies. A single injection of IL-17 in vivo exhibited stimulatory effects on hematopoietic cells from both granulocytic and erythroid lineages. The increased number of metamyelocytes 48 h after treatment imply to the IL-17-induced stimulation of granulopoiesis. The number of BFU-E was increased at 24 h, while the number of CFU-E increased 6 h and 24 h alter treatment. Since the same treatment in the bone marrow decreased the number of CFU-E, it may be concluded that the local microenvironment plays an important role in IL-17-mediated effects on CFU-E. IL-17 increased the release of lL-6 both in vitro and in vivo, but showed tendency to suppress the constitutive secretion of IL-10 by spleen cells. Our results suggest the complexity of target cell response and interplay of secondary induced cytokines by IL-17 in different hematopoietic organs. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTERLEUKINS
HEMATOPOIESIS
SPLEEN
CYTOKINES
BONE marrow
Subjects
Details
- Language :
- English
- ISSN :
- 08628408
- Volume :
- 56
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Physiological Research
- Publication Type :
- Academic Journal
- Accession number :
- 25887841
- Full Text :
- https://doi.org/10.33549/physiolres.930944