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Organochlorine Pesticides in Placentas from Southern Spain and Some Related Factors.
- Source :
- Placenta; Jul2007, Vol. 28 Issue 7, p631-638, 8p
- Publication Year :
- 2007
-
Abstract
- Abstract: During pregnancy, lipophilic xenobiotics stored in maternal adipose tissue can be mobilized and enter her blood circulation and reach the placenta. This study measured residues of oestrogen-mimicking organochlorine pesticides (OCs) in 150 placenta samples from women in Southern Spain. OCs were extracted from placenta by solid–liquid technique and purified by preparative liquid chromatography. Gas chromatography/electron-capture detection and mass spectrometry were used to identify and quantify p,p′-DDT and congeners/metabolites, endosulphan and congeners/metabolites, lindane, aldrin/dieldrin/endrin, hexachlorobenzene, methoxychlor and mirex. A mean of eight pesticides per placenta were detected (range, 3–15 pesticides). Endosulphan-ether, endosulphan-diol, endosulphan-I, p,p′-DDE, o,p′-DDD, p,p′-DDT, o,p′-DDT and lindane were detected in ≥50% of samples; p,p′-DDE was the most frequent (96.03%), followed by endosulphan-diol (76.86%) and lindane (74.17%). Presence of more pesticides was significantly associated with lower birth weight. Mean concentration of p,p′-DDE was 2.37±2.80ng/g of placenta or 76.62±104.85ng/g of lipid. Higher maternal body mass index was significantly associated with higher endosulphan concentrations in placenta, and greater maternal weight gain was significantly associated with higher p,p′-DDE concentrations. Prenatal exposure to OC xenoestrogens may be a causative factor in adverse reproductive health trends, and further studies are required to identify and describe pathways of this exposure to enhance preventive measures. [Copyright &y& Elsevier]
- Subjects :
- PREGNANCY
ADIPOSE tissues
PLACENTA
EMBRYOLOGY
XENOESTROGENS
Subjects
Details
- Language :
- English
- ISSN :
- 01434004
- Volume :
- 28
- Issue :
- 7
- Database :
- Supplemental Index
- Journal :
- Placenta
- Publication Type :
- Academic Journal
- Accession number :
- 25316629
- Full Text :
- https://doi.org/10.1016/j.placenta.2006.09.009