Hypermethylation of the Breast Cancer-Associated Gene 1 Promoter Does Not Predict Cytologic Atypia or Correlate with Surrogate End Points of Breast Cancer Risk.

Authors :: Bean, Gregory R.
Drendall, Catherine Ibarra
Goldenberg, Vanessa K.
Baker Jr., Joseph C.
Troch, Michelle M.
Paisie, Carolyn
Wilke, Lee G.
Yee, Lisa
Marcom, Paul K.
Kimler, Bruce F.
Fabian, Carol J.
Zalles, Carola M.
Broadwater, Gloria
Scott, Victoria
Seewaldt, Victoria L.
Source :: Cancer Epidemiology, Biomarkers & Prevention; Jan2007, Vol. 16 Issue 1, p50-56, 7p, 2 Diagrams, 2 Charts, 2 Graphs
Publication Year :: 2007
Abstract: The article discusses a study which investigated the role of hypermethylation of the breast cancer-associated gene 1 (BRCA1) promoter in breast cancer risk. In the study, BRCA1 promoter hypermethylation was tested in breast cancer biopsies and initial random periareolar fine-needle aspiration (RPFNA) cytologic samples. It revealed the BRCA1 is not associated with the disease and at the same time does not predict mammary atypia in RPFNA cytologic samples.

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