Relation between serum high-sensitive CRP concentration and exercise tolerance in middle-aged and elderly subjects --SAT project 188--.

The relation between high-sensitive C-reactive protein (CRP), a new coronary risk factor and exercise tolerance has not been elucidated. The aim of this study was to show the relation between the serum CRP concentration and peak oxygen uptake in 270 middle-aged and elderly subjects (67.4±6.6 years) with no cardiorespiratory diseases. Physical characteristics and blood chemistry indices were evaluated in the fasting state and peak oxygen uptake was estimated by a symptom-limited cardiopulmonary ergometer exercise test. Results: The mean serum CRP concentration was 0.637±0.715mg/L. The serum CRP concentration was significantly related to age (r=0.138, p=0.0238), body weight (r=0.183, p=0.0027), body mass index (r=0.345, p<0.0001), serum insulin concentration (r=0.187, p=0.0021), HOMA-R (r=0.171, p=0.0052), serum HDL-cholesterol concentration (r=-0.254, p<0.0001), serum LDL-cholesterol (r=0.138, p=0.0234), and peak oxygen uptake (r=-0.384, p=.0003). In stepwise multivariate analysis, only the peak oxygen uptake and BMI were significantly correlated with serum CRP concentration. In conclusion, these data suggest that exercise tolerance was independently associated with serum CRP concentration in middle-aged and elderly subjects. [ABSTRACT FROM AUTHOR]