Impaired maternal glucose homeostasis during pregnancy is associated with low status of long-chain polyunsaturated fatty acids (LCP) and essential fatty acids (EFA) in the fetus.

Abstract: Low status of long-chain polyunsaturated fatty acids (LCP) and essential fatty acids (EFA) in the fetus is associated with less favorable neonatal neurological condition. A ‘relative’, rather than ‘absolute’ EFA deficiency might explain this finding. A relative EFA deficiency may derive from impaired maternal glucose homeostasis. We measured fatty acids in umbilical vessels of infants born to 7 mothers with (gestational) diabetes mellitus and of 258 infants born to healthy mothers. Umbilical veins of infants of diabetic mothers had higher ω7 and ω9 fatty acids and DHA deficiency index and lower 20:4ω6 and EFA index. Their umbilical arteries had higher ω7 and ω9 fatty acids, and lower 20:4ω6, LCP and EFA index. We conclude that children born to mothers with poor glucose homeostasis have lower EFA and LCP status, which is consistent with a ‘relative deficiency’ deriving from augmented de novo fatty acid synthesis from the abundant glucose. [Copyright &y& Elsevier]